Pulmonary Arterial Hypertension (PAH) is a disease that
affects the vasculature of the heart, specifically the arteries that transport
blood from the heart to the lungs. Common symptoms include heart palpitations
or an irregular rhythm, chest pain, coughing, wheezing, shortness of breath,
chest discomfort when breathing, and sometimes even heart failure. The cause of
pulmonary hypertension is not known, but research has indicated that genetic
and hormonal factors may play a role in its development.
The growing prevalence of Pulmonary Arterial Hypertension
(PAH) is driving the growth of the Pulmonary Arterial Hypertension (PAH) Market. According to the European Respiratory Society, PAH is a
rare disease, with an estimated prevalence ranging from 10 to 52 cases per
million. The growing geriatric population is again increasing the prevalence of
such disease which is also projected to foster the growth of the Pulmonary
Arterial Hypertension (PAH) market. According to the United nation, by 2050,
one in six people in the world will be over age 65 (16%), up from one in 11 in
2019 (9%). By 2050, one in four persons living in Europe and Northern America
could be aged 65 or over.
North America is projected to gain significant growth over
the forecast period and this is attributed to the growing adoption of advanced
treatment for treating pulmonary arterial hypertension. Moreover, increasing
spending by the government on the healthcare sector is again augmenting the
regional market growth. According to the U.S. Centers for Medicare &
Medicaid Services, National health spending is projected to grow at an average
annual rate of 5.4 percent for 2019-28 and to reach $6.2 trillion by 2028.
Key Developments:
1. In September 2020, The Janssen Pharmaceutical Companies of
Johnson & Johnson announced the submission of a New Drug Application (NDA)
to the U.S. Food and Drug Administration (FDA) for UPTRAVI® (selexipag) as an
injection for intravenous (IV) use for the treatment of pulmonary arterial
hypertension (PAH, WHO Group I) in adults
2. In September 2020, Alembic Pharmaceuticals announced that
the subsidiary has received tentative approval from the US health regulator for
Treprostinil injection indicated for the treatment of pulmonary arterial
hypertension.
3. In April 2019, Cipla has received final approval from the
United States Food and Drug Administration (USFDA) for Ambrisentan used for
pulmonary arterial hypertension drug
4. In March 2019, Sandoz announced the US availability of
Treprostinil Injection, the first fully substitutable AP rated generic version
of Remodulin®* (treprostinil) Injection. Treprostinil is indicated for
Pulmonary Arterial Hypertension (PAH)
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